Asymmetric α-amination of 3-substituted oxindoles using chiral bifunctional phosphine catalysts

• Qiao-Wen Jin,
• Zhuo Chai,
• You-Ming Huang,
• Gang Zou and
• Gang Zhao

Beilstein J. Org. Chem. 2016, 12, 725–731, doi:10.3762/bjoc.12.72

• stereogenic carbon centers; Introduction Recently, chiral 3-substituted oxindoles have been attractive targets in asymmetric synthesis due to their abundance in the structures of numerous natural products and pharmaceutically active compounds [1]. In particular, the chiral 3-aminooxindoles containing a

• catalysts is reported. The corresponding products containing a tetrasubstituted carbon center attached to a nitrogen atom at the C-3 position of the oxindole were obtained in high yields and with up to 98% ee. Keywords: 3-aminooxindoles; asymmetric catalysis; phosphine catalyst; tetrasubstituted